New Research Supports Potential for CytoDyn’s PRO 140 to Inhibit Breast Cancer Metastasis
Study conducted in collaboration with world-renowned oncologist Dr. Richard G. Pestell shows ability of PRO 140 to block cancer invasion into healthy cells in surrogate assay for metastatic breast cancer
VANCOUVER, Washington, June 26, 2018 (GLOBE NEWSWIRE) -- CytoDyn Inc. (OTC.QB:CYDY), announces that findings from a preclinical study in a surrogate assay for metastatic breast cancer showed that PRO 140, a novel humanized CCR5 monoclonal antibody, detected CCR5 on human breast cancer cells and blocked their invasion as effectively as small molecule CCR5 inhibitors. The study was conducted in collaboration with prominent oncologist Richard G. Pestell, M.D., Ph.D., President of the Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute and Pennsylvania Biotechnology Center.
“I contacted CytoDyn last year about conducting studies with PRO 140 in metastatic breast and prostate cancer after my published research, and studies by others, had shown promising results with small molecule CCR5 antagonists in multiple cancer indications,” said Dr. Pestell. “While these are early-stage study results, it’s encouraging to find that PRO 140 detected CCR5 on highly metastatic human breast cancer cells and blocked their invasiveness. The blocking of breast cancer invasion with PRO 140 was as effective as with small molecule CCR5 inhibitors in our prior published studies. Our previous studies showed small molecular CCR5 inhibitors effectively block metastasis of human breast cancer cells to the lungs, and blocked prostate cancer cell metastasis to the bones and the brain.”
Nader Pourhassan, Ph.D., CytoDyn’s President and Chief Executive Officer, commented: “We are very encouraged that these results show that PRO 140 has the potential to block metastatic breast cancer. Based upon our human studies in HIV patients, we believe PRO 140, if approved, may offer less frequent dosing and an improved safety profile when compared to other small molecule CCR5 antagonists. This reaffirms our belief that PRO 140 may have significant opportunities beyond HIV and GvHD. We are very pleased to be collaborating in this work with Dr. Pestell and are encouraged by these findings with PRO 140.”
CCR5 and CCL5 are potential markers for metastatic cancer, and their interaction leads to increased cancer cell invasion and metastasis. Recent research by Dr. Pestell and others has shown that treatment with CCR5 inhibitors can inhibit metastasis and invasion of prostate cancer, breast cancer and colon cancer, including patients with colon cancer resistant to prior treatments. Thus, blocking CCR5/CCL5 interaction with PRO 140 may prove a useful therapeutic strategy to prevent metastasis and control cancer progression.
About PRO 140
PRO 140 belongs to a new class of HIV/AIDS therapeutics – viral-entry inhibitors – that is intended to protect healthy cells from viral infection. PRO 140 is a humanized IgG4 monoclonal antibody directed against CCR5, a molecular portal that HIV uses to enter T cells. PRO 140 blocks the predominant HIV (R5) subtype entry into T cells by masking this required co-receptor, CCR5. Importantly, PRO 140 does not appear to interfere with the normal function of CCR5 in mediating immune responses. PRO 140 does not have agonist activity toward CCR5 but does have antagonist activity to CCL5, which is a central mediator in inflammatory diseases. PRO 140 has been the subject of seven clinical trials, each demonstrating efficacy by significantly reducing or controlling HIV viral load in human test subjects. PRO 140 has been designated a “fast track” product by the FDA. The FDA also granted orphan drug designation to PRO 140 for the prevention of graft-versus-host disease (GvHD). The PRO 140 antibody appears to be a powerful antiviral agent leading to potentially fewer side effects and less frequent dosing requirements compared with daily drug therapies currently in use.
CytoDyn is a biotechnology company focused on the clinical development and potential commercialization of humanized monoclonal antibodies for the treatment and prevention of HIV infection. The Company has one of the leading monoclonal antibodies under development for HIV infection, PRO 140, which has completed Phase 2 clinical trials with demonstrated antiviral activity in humans and is currently in Phase 3 development. PRO 140 blocks the HIV co-receptor CCR5 on T cells, which prevents viral entry. Clinical trial results thus far indicate that PRO 140 does not negatively affect the normal immune functions that are mediated by CCR5. Results from seven Phase 1 and Phase 2 human clinical trials have shown that PRO 140 can significantly reduce viral burden in people infected with HIV. A recent Phase 2b clinical trial demonstrated that PRO 140 can prevent viral escape in patients during several months of interruption from conventional drug therapy. CytoDyn intends to continue to develop PRO 140 as a therapeutic anti-viral agent in persons infected with HIV and to pursue non-HIV, inflammatory indications where CCR5 and its ligand CCL5 may be involved. For more information on the Company, please visit http://www.cytodyn.com.
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LHA Investor Relations
Joan E. Kureczka
Released June 26, 2018